출처: 당사 내부자료

출처: EvaluatePharma 2023

계약상대방으로부터 의약품(계약 물질)을 무상으로 지원받고 있으며, 의약품 지원규모는 다음과 같습니다.

주1)

[논문] Cytotoxic and Apoptotic Effects of Echinomycin on murine leukemia cells. Kim TU, Yang SH, and Kim SK. J. Biochem. Mol. Biol. (1996) 29, 489-492. (co-author)

[논문] Comparison of various expression plasmids for the induction of immune response by DNA immunization. Lee AH, Suh YS, Sung JH, Yang SH, and Sung YC Mol Cells (1997) 31, 495-501. (co-author)

[논문] Hepatitis C virus core from two different genotypes has an oncogenic potential but is not sufficient for transforming primary rat embryo fibroblasts in cooperation with the H-ras oncogene. Chang J*, Yang SH*, Cho YG, Hwang SB, Hahn YS, and Sung YC J Virol (1998) 72, 3060-3065. (co-first author)

[논문] Hepatitis C virus core from two different genotypes has an oncogenic potential. S.H. Yang, J. Chang, Y.G. Cho and Y.C. Sung. Hepatitis Weekly. April 27, (1998) pp10-11. (first author)

[논문] In vivo assay for hepatitis C viral serine protease activity using a secreted protein. Cho YG*, Yang, SH*, and Young Chul Sung, J. of Virological Methods. (1998) 72, 109-115. (co-first author)

[논문] Internal cleavage of Hepatitis C virus NS3 protein is dependent on the activity of NS34A protease. Se-Hwan Yang, Chang Geun Lee, Man Ki Song and Young Chul Sung Virology (2000) 268, 132-140. (first author)

[논문] Hepatitis C virus core protein inhibits interleukin 12 and nitric oxide production from activated macrophages. Chu Hee Lee, Yo Han Choi, Se Hwan Yang, Chang Woo Lee, Sang Jun Ha, and Young Chul Sung, (2001) Virology, 279, 271-279. (co-author)

[논문] HCV core protein modulates Rb pathway through pRb down-regulation and E2F-1 up-regulation. Jae-We Cho, Won-Ki Baek, Seong-Il Suh, Se-Hwan Yang, Jung Chang, Young Chul Sung and Min Ho Suh, Biochimica et Biophysica Acta, (2001) 1538, 59-66. (co-author)

[논문] Hepatitis C virus core protein promotes cell proliferation through the upregulation of cyclin E expression levels. Jae-We Cho, Won-Ki Baek, Seong-Il Suh, Se-Hwan Yang, Jung Chang, Young Chul Sung and Min Ho Suh, (2001) Liver, 21, 137-142. (co-author)

[논문] Hepatitis C virus core Inhibits Fas-mediated p38 mitogen activated kinase signaling pathway in hepatocytes. Se-Hwan Yang, CG Lee, CW Lee, EJ Choi, SK Youn, KS Ahn and Young Chul Sung, Mol. Cells. 2002 30;13(3):452-62. (first author)

[논문] Efficient induction of T helper 1 CD4+ T-cell responses to hepatitis C virus core and E2 by a DNA prime-adenovirus boost. Su-Hyung Park*, Se-Hwan Yang*, Chang Geun Lee, Jin-Won Youn, Jun Chang and Young Chul Sung, (2003) Vaccine 21, 4555-4564. (co-first author)

[논문] The role of hepatitis C virus core protein on liver fibrogenesis: A study using an In vitro Co-culture system. Ju Yeop Shin, Seung Kew Yoon, Jin Sang Wang, Wonhee Hur, Jong Soon Ryu, Si Hyun Bae, Jong Young Choi, Jin Mo Yang, Se-Hwan Yang, Young Chul Sung, Kyu Won Chung and Hee Sik Sun. Korean J of Gastroenterolgy, 2003, 42(5): 400-408. (co-author)

[논문] HCV core protein promotes liver fibrogenesis via up-regulation of CTGF with TGF-beta1. Shin JY, Hur W, Wang JS, Jang JW, Kim CW, Bae SH, Jang SK, Yang SH, Sung YC, Kwon OJ, Yoon SK. Exp Mol Med. 2005 Apr 30;37(2):138-45. (co-author)

[논문] Sustained E2 antibody response correlates with reduced peak viremia after hepatitis C virus infection in chimpanzee. Jin-Won Youn, Su-Hyung Park, Chang Geun Lee, Se-Hwan Yang, Hyun-Tak Jin, Chang-Min Kim, Dimitri Lavillette, Francois-Loic Cosset, Mohamed Tarek M. Shata, Dong-Hun Lee, Wolfram Pfahler, Alfred M. Prince, and Young Chul Sung. Hepatology 2005 42: 1429 - 1436. (co-author)

[논문] Efficient Induction of Th1-type Immune Responses to Hepatitis B Virus Antigens by DNA Prime-Adenovirus Boost. Chang Geun Lee*, Se-Hwan Yang*, Su-Hyung Park, Man Ki Song, So Young Choi and Young Chul Sung. Immune network 2005 5; 1 - 10. (co-first author)

[논문] Correlation of antiviral T cell responses with suppression of viral rebound in chronic hepatitis B carriers: a proof-of-concept study. S-H Yang, C-G Lee, S-H Park, S-J Im, Y-M Kim, J-M Son, J-S Wang, S-K Yoon, M-K Song, A Ambrozaitis, N Kharchenko, Y-D Yun, C-M Kim, C-Y Kim, S-H Lee, B-M Kim, W-B Kim, and Y-C Sung. Gene Therapy (2006 13: 1110-1117). (first author)

[논문] Relationship between T cell responses and suppression of viral rebound in chronic hepatitis B carriers received combination therapy with DNA vaccine and chemical drug. Yang SH, Lee CG, Park SH, Im SJ, Son, JM, Wang JS, Yoon SK, Ambrozaitis A, Kharchenko N, Kim CY, Kim BM, Sung YC, J. of Clinical Virology, 2006. July 36, S29. (first author)

[논문] In vivo kinetics and biodistribution of HB-110, a novel HBV DNA vaccine, after administration in mice. Kang, ES, Kim CY, Kim SH, Im SJ, Yang SH, Sung YC, and Kim BM. Archives of Pharmacal Research, 2007 Mar; 30(3): 355-60. (co-author)

[논문] Adenovirus-mediated gene transfer of interleukin-23 shows prophylactic but not     therapeutic antitumor effects. HT Jin, JI Youn, SY Choi, SH Seo, SH Park, MY     Song, SH Yang and YC Sung. Cancer Gene Ther. 2008 Nov;15(11):693-702. (co-author)

[논문] Increased in vivo immunological potency of HB-110, a novel therapeutic HBV DNA vaccine, by electroporation. Kim CY, Kang ES, Kim SB, Kim HE, Choi JH, Lee DS, Im SJ, Yang SH, Sung YC, Kim BM, Kim BG. Exp Mol Med. 2008 Dec 31;40(6):669-76. (co-author)

[논문] Marked enhancement of antigen-specific T-cell responses by IL-7-fused nonlytic, but not lytic, Fc as a genetic adjuvant. Nam HJ, Song MY, Choi DH, Yang SH, Jin HT, Sung YC. Eur J Immunol. 2010 Feb;40(2):351-8. (co-author)

[논문] Increase of Plasma IL-12/p40 Ratio Induced by the Combined Therapy of DNA Vaccine and Lamivudine Correlates with Sustained Viremia Control in CHB Carriers. Im SJ, Yang SH, Yoon SK, Sung YC. Immune Netw. 2009 Feb;9(1):20-6. (co-author)

[논문] Natural form of noncytolytic flexible human Fc as a long-acting carrier of agonistic ligand, erythropoietin. Im SJ, Yang SI, Yang SH, Choi DH, Choi SY, Kim HS, Jang do S, Jin KS, Chung YK, Kim SH, Paik SH, Park YC, Chung MK, Kim YB, Han KH, Choi KY, Sung YC. PLoS One. 2011;6(9):e24574. doi: 10.1371/journal.pone.0024574. Epub 2011 Sep 16. (co-author)

[논문] Dendritic cell internalization of α-galactosylceramide from CD8 T cells induces potent antitumor CD8 T-cell responses. Choi DH, Kim KS, Yang SH, Chung DH, Song B, Sprent J, Cho JH, Sung YC. Cancer Res. 2011 Dec 15;71(24):7442-51 (co-author)

[논문] A long-acting erythropoietin fused with noncytolytic human Fc for the treatment of anemia. Yang SH, Yang SI, Chung YK. Arch Pharm Res. 2012 May;35(5):757-9. doi: 10.1007/s12272-012-0500-5. Review. (corresponding author)

[논문] Biochemical characterization of a new recombinant TNF receptor-hyFc fusion protein expressed in CHO cells. Lee JH, Yeo J, Park HS, Sung G, Lee SH, Yang SH, Sung YC, Kang JH, Park CS. Protein Expr Purif. 2013 Jan;87(1):17-26. doi: 10.1016/j.pep.2012.09.001. Epub 2012 Sep 23.(co-author)

[논문] The pharmacology study of a new recombinant TNF receptor-hyFc fusion protein. Lee JH, Cho JH, Yeo J, Lee SH, Yang SH, SungYC, KangJH, ParkCS. Biologicals. 2013 Mar;41(2):77-83. (Co-author)

[논문] Safety and immunogenicity of therapeutic DNA vaccine with antiviral drug in chronic HBV patients and its immunogenicity in mice. Yoon SK, Seo YB, Im SJ, Bae SH, Song MJ, You CR, Jang JW, Yang SH, Suh YS, Song JS, Kim BM, Kim CY, Jeong SH, Sung YC. Liver Int. 2014 Mar 13. doi: 10.1111/liv.12530. [Epub ahead of print] (Co-author)

[논문] Crucial roles of interleukin-7 in the development of T follicular helper cells and in the induction of humoral immunity. Seo YB, Im SJ, Namkoong H, Kim SW, Choi YW, Kang MC, Lim HS, Jin HT, Yang SH, Cho ML, Kim YM, Lee SW, Choi YK, Surh CD, Sung YC. J Virol. 2014 Aug;88(16):8998-9009. doi: 10.1128. (Co-author)

[논문] Irradiation-induced localization of IL-12-expressing mesenchymal stem cells to enhance the curative effect in murine metastatic hepatoma. Jeong KY, Lee EJ, Kim SJ, Yang SH, Sung YC, Seong J. Int J Cancer. 2015 Aug 1;137(3):721-30. doi: 10.1002 (Co-author)

[논문] IL-12p40 Homodimer Ameliorates Experimental Autoimmune Arthritis. Lee SY, Jung YO, Kim DJ, Kang CM, Moon YM, Heo YJ, Oh HJ, Park SJ, Yang SH, Kwok SK, Ju JH, Park SH, Sung YC, Kim HY, Cho ML. J Immunol. 2015 Oct 1;195(7):3001-10. doi: 10.4049 (Co-author)

[논문] (p40)2-Fc reduces immune-inflammatory response through the activation of T cells in collagen induced arthritis mice. Lee SY, Lee SH, Park SJ, Kim DJ, Kim EK, Kim JK, Yang SH, Park SH, Sung YC, Kim HY, Cho ML. Immunol Lett. 2016 Aug;176:36-43. doi: 10.1016 (Co-author)

[논문] hIL-7-hyFc, A Long-Acting IL-7, Increased Absolute Lymphocyte Count in Healthy Subjects. Sang Won Lee, Donghoon Choi, MinKyu Heo, Eui-Cheol Shin , Su-Hyung Park , So Jeong Kim , Yeon-Kyung Oh, Byung Ha Lee , Se Hwan Yang, Young Chul Sung, Howard Lee Clin Transl Sci 2020 Nov 13 (6): 1161-1169 (Co-author)

주2)

[논문] Preclinical safety assessment of a therapeutic human papillomavirus DNA vaccine combined with intravaginal interleukin-7 fused with hybrid Fc in female rats, Toxicology and Applied Pharmacology, February 2021

[논문] Hybrid Fc-fused interleukin-7 induces an inflamed tumormicroenvironment and improves the efficacy of cancerimmunotherapy. Clinical & Translational Immunology, September 2020

[논문] hIL-7-hyFc, A Long-Acting IL-7, Increased Absolute Lymphocyte Count in Healthy Subjects. Clin Transl Sci . April 2020

[논문] Plasmacytoid Dendritic Cells Contribute to the Protective Immunity Induced by Intranasal Treatment with Fc-fused Interleukin-7 against Lethal Influenza Virus Infection. Immune Netw. December 2017

[논문] Intravaginal administration of Fc-fused IL-7 suppresses the cervicovaginal tumor by recruiting HPV DNA vaccine-induced CD8 T cells, Clin Cancer Res. December 2016

[논문] Biophysical stability of hyFc fusion protein with regards to buffers and various excipients. Int J Biol Macromol. May 2016

[논문] Intranasal Introduction of Fc-Fused Interleukin-7 Provides Long-Lasting Prophylaxis against Lethal Influenza Virus Infection, J Virol, December 2015

[논문] Effect of DNA vaccine following PD-1/IL-10R blockade treatment in two chimpanzees chronically infected with HCV Gene Ther Mol Biol, January 2013

[논문] Enhancement of antigen-specific CD8 T cell responses by co-delivery of Fc-fused CXCL11. Vaccine, February 2014

[논문] Nonlytic Fc-fused IL-7 synergizes with Mtb32 DNA vaccine to enhance antigen-specific T cell responses in a therapeutic model of tuberculosis. Vaccine, June 2013

[논문] The past, present, and future of adoptive T cell therapy. Immune Network, August 2012

[논문] Dendritic cell internalization of α-galactosylceramide from CD8 T cells induces potent antitumor CD8 T cell response. Cancer Research. December 2011

[논문] Natural form of noncytolytic flexible human Fc as a long-acting carrier of agonistic ligand, erythropoietin. PLoS One, September 2011

[논문] Enhancement of Vaccine-induced Primary and Memory CD8+ T-cell Responses by Soluble PD-1. J Immunother, April 2011

[논문] Marked enhancement of antigen-specific T-cell responses by IL-7-fused nonlytic, but not lytic, Fc as a genetic adjuvant. Eur J Immunol, February 2010

[학회발표 및 포스터] 2013. Complete protection against influenza virus infections (H5N2, H1N1) by engineered IL-7. International Meeting of the federation of Korean microbiological societies, Korea 

[학회발표 및 포스터] 2012. Induction of potent CD8 T cell response via internalization of cell-associated α-galactosylceramide to dendritic cells. The 12th International Symposium on Dendritic Cells, Korea 

[학회발표 및 포스터] 2012. Dendritic cell internalization of α-galactosylceramide from CD8 T cells induces potent antitumor CD8 T cell response. Keystone Symposia, USA 

[학회발표 및 포스터] 2012. Dendritic cell internalization of α-galactosylceramide from CD8 T cells induces potent antitumor. The Korean Association of Immunologists, Korea 

[학회발표 및 포스터] 2012. Dendritic cell internalization of α-galactosylceramide from CD8 T cells induces potent antitumor CD8 T cell response. The 13th Korean dendritic cell symposium, Korea 

[학회발표 및 포스터] 2012. NKT cells and their application for immunotherapy. 4th Winter Symposium of the Korean society for transplantation, Korea 

[학회발표 및 포스터] 2011. Dendritic cell internalization of α-galactosylceramide from CD8 T cells induces potent antitumor CD8 T cell response. The Korean Association of Immunologists, Korea 

[학회발표 및 포스터] 2007. The adjuvant effect of α-galactosylceramide on induction of Type I T cell response by HBV DNA vaccine in Balb/c mouse and HBV Transgenic mouse. Symposium & Workshop on Innate & Adaptive Immunity in Chronic Hepatitis B & C Virus abstract, Korea 

주3)

[논문] “Hybrid Fc-fused interleukin-7 induces an inflamed tumor microenvironment and improves the efficacy of cancer immunotherapy” in Clin Transl Immunology. 2020 Sep 4;9(9):e1168. doi: 10.1002/cti2.1168. eCollection 2020.

[논문] “Innovative CAR-T Cell Therapy for Solid Tumor; Current Duel between CAR-T Spear and Tumor Shield” in Cancers (Basel). 2020 Jul 28;12(8):2087. doi: 10.3390/cancers12082087

[논문] “hIL-7-hyFc, A Long-Acting IL-7, Increased Absolute Lymphocyte Count in Healthy Subjects” in Clin Transl Sci. 2020 Nov;13(6):1161-1169. doi: 10.1111/cts.12800. Epub 2020 May 20.

[논문] “Programmed cell death ligand 1 alleviates psoriatic inflammation by suppressing IL-17A production from programmed cell death 1-high T cells” in J Allergy Clin Immunol., 2016, Jan 26. pii: S0091-6749(16)00022-1

[논문] “Autoantibodies against muscarinic type 3 receptor in Sjgren’s syndrome inhibit aquaporin 5 trafficking” in PLoS One, 2013;8(1):e53113. doi: 10.1371/journal.pone.0053113. Epub 2013 Jan 30

[논문] “Gene therapy using interleukin-27 ameliorates Sjogren’s syndrome-like autoimmune exocrinopathy” in Arthritis Research & Therapy. 2012 Jul 24;14(4):R172

[논문] “Animal models in autoimmune diseases: Learned from mouse model for Sjogren’s syndrome” in Clinical Reviews in Allergy and Immunology. 42(1):35-44, 2012

[논문] “Mechanisms of salivary gland secretory dysfunction on Sjogren’s syndrome” in Rheumatic Diseases, ISBN 978-953-307-846-5, InTech Open Access Publisher, 2012

[논문] “Current Concepts: Mouse Models of Sjogren's Syndrome” in Journal of Biomedicine and Biotechnology, 2011:549107. Epub 2010 Dec 30. Review, 2011

[논문] “IL17: potential therapeutic target in Sjogren's syndrome using adenovirus-mediated gene transfer” in Laboratory Investigation, 91(1):54-62, 2011

[논문] “Pathogenic effect of interleukin-17A in induction of Sjogren's syndrome-like disease using adenovirus-mediated gene transfer” in Arthritis Research & Therapy, 12(6):R220, 2010

[논문] “Sjogren’s syndrome: An old tale with a new twist” in Archivum Immunologiae et Therapiae Experimentalis (Warsz), 57(1):5766, 2009

[논문] “Identification of proteins that interact with podocin using the yeast 2-hybrid system” in Yonsei Medical Journal, 30;50(2):273-9, 2009

[논문] “Differential gene expression in the salivary gland during development and onset of xerostomia in Sjogren's syndrome-like disease of the C57BL/6.NOD-Aec1Aec2 mouse” in Arthritis Research & Therapy, 11(2):R56, 2009

[논문] “Identification of possible candidate genes regulating Sjogren's syndrome- associated autoimmunity: a potential role for TNFSF4 in autoimmune exocrinopathy” in Arthritis Research & Therapy , 25;10(6):R137, 2008

[논문] “Coating with Paclitaxel Improves Graft Survival in a Porcine Model of Haemodialysis Graft Stenosis” in Nephrology Dialysis Transplantation, 22(10):2800-2804, 2007

[논문] “A Novel Technique for Loading of Paclitaxel-PLGA Nanoparticles onto ePTFE Vascular Grafts" in Biotechnology Progress, 23:693-697, 2007

[논문] “Paclitaxel-coated expanded polytetrafluoroethylene hemodialysis graft inhibit neointimal hyperplasia in porcin model of graft stenosis" in Nephrology Dialysis Transplantation , 21:2432- 2438, 2006

[논문] “Insulin Microcrystal Suspension as a long-acting Formulaiton for Pulmonary Delivery” in European Journal of Pharmaceutical Sciences, 22:107-116, 2004

[학회발표 및 포스터] “Hyleukin-7, the Fc-fused interleukin-7, generates anti-tumor activity by modulating both adaptive and innate immune cells in the tumor microenvironment” at the AACR 2019, Georgia World Congress Center Atlanta, Georgia, USA, March 29- April 3, 2019

[학회발표 및 포스터] “Hyleukin-7, a long-acting interleukin-7, increased absolute lymphocyte counts after subcutaneous and intramuscular administration in healthy subjects” at the AACR 2019, Georgia World Congress Center Atlanta, Georgia, USA, March 29- April 3, 2019

[학회발표 및 포스터] “Modeling Sezary syndrome for immunophenotyping and anti-tumor effect of UCART and long-acting interleukin-7 combination therapy” at TCT 2019, Houston, TX, USA, Feb 20-24, 2019

[학회발표 및 포스터] “A long-acting pharmacological grade interleukin-7 molecule logarithmically accelerates UCART proliferation, differentiation, and tumor killing” at TCT 2019, Houston, TX, USA, Feb 20-24, 2019

[학회발표 및 포스터] “Modeling Sezary syndrome for immunophenotyping and anti-tumor effect of UCART and long-acting interleukin-7 combination therapy” at ASH 2018, San Diego, CA, USA, December 1-4, 2018

[학회발표 및 포스터] “A long-acting pharmacological grade interleukin-7 molecule logarithmically accelerates UCART proliferation, differentiation, and tumor killing” at ASH 2018, San Diego, CA, USA, December 1-4, 2018

[학회발표 및 포스터] “Preclinical evaluation of the anti-tumor activity of Fc-fused interleukin-7 in both monotherapy and combination therapy” at the AACR 2018, McCormick Place, Chicago, Illinois, USA, April 14-18, 2018

주4) 

[논문] RORα is crucial for attenuated inflammatory response to maintain intestinal homeostasis.,  10. 2019

[논문] Structural and Molecular Basis for Katanin-Mediated Severing of Glutamylated Microtubules.,01.2019

[논문] Dedifferentiated Schwann cells secrete progranulin that enhances the survival and axon growth of motor neurons, 02 2019

[논문] Mouse Cre-LoxP system: general principles to determine tissue-specific roles of target gene,12.2018

[논문] Asxl1 exerts an antiproliferative effect on mouse lung maturation via epigenetic repression of the E2f1-Nmyc axis 11.2018

[논문] Anisotropically organized three-dimensional culture platform for reconstruction of a hippocampal neural network 02.2017

[논문] Functional Characterization of Resting and Adenovirus-Induced Reactive Astrocytes in Three-Dimensional Culture 06.2017

[논문] Effects of microtubule stabilization by Epothilone B depend on the type and age of neurons,10 2016

[논문] Inflammatory signals induce the expression of tonicity-responsive enhancer binding protein(TonEBP) in microglia,04.2016

[논문] Collagen-based brain microvasculature model in vitro using three-dimensional printed template,04.2015

[논문] Direct Interaction and Functional Coupling between Human 5-HT6 Receptor and the Light Chain 1 Subunit of the Microtubule-Associated Protein 1B (MAP1B-LC1),03.2014

[논문] Meteorin Regulates Mesendoderm Development by Enhancing Nodal Expression

[논문] Disruption of sorting nexin 5 causes respiratory failure associated with undifferentiated alveolar epithelial type I cells in mice.

[논문] Cardiomyocyte specific deletion of Crif1 causes mitochondrial cardiomyopathy in mice.

[논문] Vaccinia-Related Kinase 1 Is Required for the Maintenance of Undifferentiated Spermatogonia in Mouse Male Germ Cells

[논문] Inactivation of Notch signaling in the renal collecting duct causes nephrogenic diabetes insipidus in mice.

[논문] Mind bomb 1 in the lymphopoietic niches is essential for T and marginal zone B cell development

[논문] Mind bomb 1-expressing intermediate progenitors generate notch signaling to maintain radial glial cells.

[논문] Crif1 is a novel transcriptional coactivator of STAT3

[논문] An Obligatory Role of Mind Bomb-1 in Notch Signaling of Mammalian Development

주5)

[논문] Analytical method validation for impurity profile of human albumin protein with HPLC, August 2004.

주6)

[논문] TNF-α levels in HIV-infected patients after long-term suppressive cART persist as high as in elderly, HIV-uninfected subjects. 2014 J Antimicrob Chemother 69:3041-3046 

[논문] Functional exhaustion of HBV-specific CD8 T cells impedes anti-PD-L1 blockade efficacy in chronic HBV infection. 2020. Submitted to Gastroenterology. 

[논문] HBeAg seroconversion is associated with a more effective PD-L1 blockade during chronic Hepatitis B infection. 2019. J Hepat Reports. 1:170-178. 

[논문] Accumulation of follicular CD8+ T cells in pathogenic SIV infection. 2018. J Clin Invest. 128:2089-2103  

[논문] Increased CD127+ and decreased CD57+ T cell expression levels in HIV-infected patients on NRTI-sparing regimens. 2017. J Transl Med. 15:259. (* These authors contributed equally to this work) 

[논문] Thymic function failure is associated with HIV-disease progression. 2017. Clin Infect Dis, 64:1191-1197.  

[논문] Follicular CD8 T cells accumulate in HIV infection and can kill infected cells in vitro via bispecific antibodies. 2017 Sci Transl Med, 18:9(373). (* These authors contributed equally to this work) 

[논문] Pre-transplant thymic function is associated with the risk of cytomegalovirus disease after solid organ transplantation. 2015 Clin Microbiol Infect 21:511.e1-7 (* These authors contributed equally to this work) 

[논문] IFNγ-TNFα-IL2-MIP1α-CD107a+PRF1+ CD8 pp65-Specific T-Cell Response Is Independently Associated With Time to Death in Elderly Humans. 2015 J Gerontol A Biol Sci Med Sci  70:1210-18 

[논문] WNT signaling in the senescent human thymus. J Gerontol A Biol Sci Med Sci 2015 70:273-81 

[논문] Low thymic output, peripheral homeostasis deregulation, and hastened regulatory T cells differentiation in children with 22q11.2 deletion syndrome. J Pediatr 2014; 164:882-889 

[논문] Impact of thymic function in age-related immune deterioration. Rev Esp Geriatr Gerontol 2013; 48:232-237 [Spanish] 

[논문] Differential gag-specific polyfunctional T cell maturation patterns in HIV-1 Elite Controllers. J Virol 2012; 86:3667-3774  

[논문] Thymic function failure and C-reactive protein levels are independent predictors of all-cause mortality in healthy elderly humans. AGE (Dodr) 2013; 35:251-259   

[논문] HIV infection-related premature immunosenescence: high rates of immune exhaustion after short time of infection. Current HIV Res.2011; 9:289-294  

[논문] Simplified sequence-specific oligonucleotide (SSO)-based PCR protocol to characterize human MHC A*02 and MHC A*24 specificities. Hum Immunol. 2011; 72:869-871  

[논문] Age-related deregulation of naive T cell homeostasis in elderly humans. AGE (Dordr). 2011; 33:197-207  

[논문] A reliable and simplified sj/β-TREC ratio quantification method for human thymic output measurement. J Immunol Methods 2010; 352:111-117  

[논문] CD27 and CCR7 expression on naive T cells, are both necessary Immunol Lett 2010; 127:157-158.  

[논문] Thymopoiesis in elderly human is associated with systemic inflammatory status. AGE (Dordr) 2009; 31:87-97.  

[논문] Immunotherapy initiated on Day 3 or 14 after SHIV infection of Rhesus Macaques can control viremia for several years. Manuscript in preparation. 

[논문] The association between residential proximity to brownfield sites and high-traffic areas and measures of immunity. 2020. Environ Epidemiol. Online ahead of print. 

[논문] Development of immature CD4+CD8+ T cells into mature CD4+ T cells requires Alpha-1 Antitrypsin as observed by treatment in HIV-1 infected and uninfected controls. 2019. Front Cell and Develop Biology. 7:278. 

[논문] Immune correlates of natural HIV Elite controllers and simultaneous HCV clearance  Supercontrollers. 2018. Front Immunol. 9:2897. 

[논문] The great recession and Immune function. 2018. RSF. 4:62-81 

[논문] Circulating metabolomic profile can predict dyslipidemia in HIV patients undergoing antiretroviral therapy. 2018. Atherosclerosis. 273:289-36. 

[논문] HIV-specific CD8+ T cells exhibit reduced and differentially regulated cytolytic activity in lymphoid tissue. 2017. Cell Rep. 21:3458-3470. 

[논문] The effects of prebiotics on microbial dysbiosis, butyrate production and immunity in HIV-infected subjects. 2016. Mucosal Immunol. 10:1279-1293.  

[논문] Tuberculosis therapy modifies the cytokine profile, maturation state, and expression of inhibitory molecules on Mycobaterium tuberculosis-specific CD4+ T cells. 2016. PLoS one. 11:e0158262

[논문] Population distributions of thymic function in adults: variation by sociodemographic characteristics and health status. 2016. Biodemography Soc Biol. 62:208-221 

[논문] Selective loss of early differentiated, highly functional PD1 high CD4 T cells with HIV progression. 2015. PLoS One. 10:e0144767 

[논문] HIV-1/HAART-related lipodistrophy syndrome (HALS) is associated with decreased circulating sTWEAK levels. 2015. PLoS One. 10:e0144789 

[논문] Monocyte phenotype and polyfunctionality are associated with elevated soluble inflammatory markers, cytomegalovirus infection and functional and cognitive decline in elderly adults. 2016. J Gerontol A Biol Med Sci. 71:610-618 

[논문] HIV-1 Lipodistrophy Study Group. HIV/antiretroviral therapy-related lipodistrophy syndrome (HALS) is associated with higher RBP4 and lower omentin in plasma. 2015 Clin Microb Infect 21:711.e1-8 

[논문] Altered metabolism of gut microbiota contributes to chronic immune activation in HIV-infected individuals. 2015 Mucosal Immunol 8:760-772 

[논문] HIV Controllers Consortium of the AIDS Spanish Network. Differential microRNA expression profile between stimulated PBMCs from HIV-1 infected elite controllers and viremic progressors. 2014 PLoS One 16:e106360 

[논문] Intrisec TGF-β signaling promotes age-dependent CD8+ T cell polyfunctionality attrition. 2014 J Clin Invest 124:2441-2455 

[논문] New advances in CMV and immunosenescence. Exp Gerontol 2014 55:54-62 

[논문] Reduced sTWEAK and increased sCD163 levels in HIV-infected patients: modulation by antiretroviral treatment, HIV replication and HCV co-infection. PLoS One 2014: 9:e90541 

[논문] Involvement of the LPS-LPB-CD14-TLR4 inflammation pathway in HIV-1/HAART-associated lipodistrophy syndrome (HALS). J Antimicrob Chemother 2014; 69:1653-1659 

[논문] Hepatitis C therapy with interferon-α and ribavirin reduces CD4 T-cell-associated HIV-1 DNA in HIV-1/hepatitis C virus-coinfected patients. J Infect Dis 2014; 209:1315-1320

[논문] Long-term suppressive combined antiretroviral treatment does not normalize serum sCD14 levels. J Infect Dis 2013; 207:1221-1225 

[논문] the HIV Controllers Consortium of the AIDS Spanish Network. IL28B single nucleotide polymorphism, rs12979860, is associated with spontaneous HIV control in Caucasian subjects. J Infect Dis 2012; 207:651-655 

[논문] CMV and Immunosenescence: from basics to clinics. Immun Ageing 2012; 9:23  

[논문] The role of defective thymic function in onset of ganciclovir-resistant cytomegalovirus after cord blood transplantation. Clin Vaccine Immunol 2012; 19:1994-1998  

[논문] Effect of maraviroc on HIV-disease progression-related biomarkers. Antimicrob Agents Chemother 2012; 56:5858-5864  

[논문] Patients on a combined antiretroviral therapy after Maraviroc Clinical Test show no immunovirological impairment. Antiviral Res 2012; 95:207-211  

[논문] Specific patterns of CD4-associated immunosenescence in vertically HIV-infected subjects. Clin Microbiol Infect 2012; 19:558-565  

[논문] Differential biological significance of sCD14 and LPS in HIV-infection: Importance of the Immunovirology stage and association with HIV-disease progression markers. J Infect 2012; 65:431-438  

[논문] Detectable viral load aggravates immunosenescence features of CD8 T-cell subsets in vertically HIV-infected children. J Acquir Immune Defic Syndr 2012; 60:447-454 

[논문] HIV-1 tropism evolution after short-term maraviroc monotherapy in HIV-1 infected patients. Antimicrob Agents Chemother 2012; 56:3981-3983 

[논문] Preterm neonates show marked leukopenia and lymphopenia that is associated with increase regulatory T-cell values and diminished IL-7. Ped Res 2012; 71:590-597 

[논문] CD4 T-cell regeneration in HIV-1 elite controllers. AIDS 2012; 26:701-706  

[논문] Correlation of the virological response to short-term Maraviroc monotherapy with standard and deep sequencing-based genotypic tropism methods. Antimicrob Agents Chemother 2012; 56:1202-1207  

[논문] Virological response after short-term CCR5 antagonist exposure in HIV-infected pateints: frequency of subjects with virological response and associated factors. Antimicrob Agent Chemother. 2011; 55:4664-4669

[논문] CD300a is expressed on human B cells, modulates BCR mediated signaling and its expression is down-regulated in HIV infection. Blood. 2011; 117:5870-5880.  

[논문] Hepatitis C virus replication in caucasian HIV controllers. J Viral Hepatitis. 2011; 18:e350-e357.  

[논문] HIV infection and aging. AIDS Rev. 2010; 12: 218-230.  

[논문] Discordance rates between Trofile test and short-term virological response to maraviroc. Antiviral Res. 2011; 89:182-185.  

[논문] a new phenotypic tropism test and its correlation with TROFILE® (ES) and genotypic approaches. J Clin Microbiol. 2010; 48:4453-4458. 

[논문] Long-term immunovirological effect and tolerability of a maraviroc-containing regimen in routine clinical practice. Curr HIV Res. 2010; 8: 482-486  

[논문] High levels of CD57+CD28- T-cells, low T-cell proliferation and preferential expansion of terminally differentiated CD4+ T-cells in HIV-Elite Controllers.  Curr HIV Res. 2010; 8: 471-481  

[논문] Correlation between the Trofile test and virological response to a short-term maraviroc exposure in HIV-infected patients. J Antimicrob Chemother 2009; 64:845-849.  

[논문] Premature immunosenescence in HIV-infected patients on highly active antirretroviral therapy with low-level CD4 T cell repopulation. J Antimicrob Chemother 2009; 64:579-588.

[학회발표 및 포스터] Immune activation drives accumulation of follicular CTL during chronic SIV/HIV infection. Keystone Symposia Conference, X7: HIV persistence: Pathogenesis and Eradication. Lake Tahoe, California March 20-24 2016 (Oral presentation).

[학회발표 및 포스터] Follicular CTL accumulate in SIV-infected lymph nodes due to immune activation. CROI, Boston February 22-25 2016 (Oral presentation)

[학회발표 및 포스터]] Bispecific antibody-mediated killing of HIV-infected cells by follicular CD8 T cells. 2015 Keystone Symposia Conference. X5: HIV vaccines. Banff, Alberta, Canada March 22-27 2015 (Oral presentation)

[학회발표 및 포스터] Redirected killing of HIV-infected T cells by germinal center CD8 T cells. CROI, Seattle February 23-27 2015 (Oral presentation) 

[학회발표 및 포스터] Inflammatory status in residual immunodeficiency under cART in HIV-infected patients. International Congress of Immunology 2013, 22-27 August, Milan (Poster) 

[학회발표 및 포스터]] WNT/CTNNB1 pathway inhibition guides the human thymic involution process. European Congress of Immunology 2012, 5-9 September, Glasgow (Poster)

[학회발표 및 포스터] CMV-specific T cells with highly effector capacity are associated with two-year all-cause mortality in healthy elderly individuals. European Congress of Immunology 2012, 5-9 September, Glasgow (Poster)

[학회발표 및 포스터] Differential HIV-specific polyfunctional T cell maturation patterns in elite controllers. EACS 2011, 12-16 Octubre 2011, Belgrado (Poster)

[학회발표 및 포스터] Thymic function and inflammation markers are independently associated with elderly human survival rates. VII IAGG European Congress “Healthy and active aging for all Europeans  II”, Bologna, April 2011 (Oral presentation) 

[학회발표 및 포스터] “Age-related deregulation of naive T cell homeostasis in elderly human”. 7th European Congress of Biogerontology. Palermo, 2010. (Oral presentation) 

[학회발표 및 포스터] "Evidence of a maintained thymopoiesis in the elderly and its role in the homeostasis of the peripheral naive T cell pool". 5th European congress of Biogerontology. Turkey, 2006. (Oral presentation).

주7)

[논문] Efficient Development of Stable Recombinant Chinese Hamster Ovary (rCHO) Cell Lines to Produce Antibodies by Using Dimethyl Sulfoxide (DMSO) in Electroporation, Journal of Microbiology and Biotechnology, October 2018

[논문] Regulation of Vascular Endothelial Growth Factor Signaling by miR-200b, Molecular Cells, May 2011

[논문] Characterization of microRNAs regulating cyclooxygenase-2 gene expression, Genes & genomics, December 2011

[논문] Inhibition of cell proliferation and migration by miR-509-3p that targets CDK2, Rac1, and PIK3C2A, Molecular Cells, April 2014

[논문] The seed sequence is necessary but insufficient for downregulation of target genes by miR-608, Genes & genomics, April 2016

[논문] Overproduction of recombinant human bone morphogenetic protein-7 in Chinese hamster ovary cells, Protein Expression and Purification, December 2015 

[논문] Induction of growth arrest by miR-542-3p that targets surviving, FEBS letters, September 2010

[논문] MiR-542-3p exerts tumor suppressive functions in neuroblastoma by downregulating Survivin, International Journal of Cancer, March 2015

[논문] MicroRNA library screening Identifies Growth-SUPpRESsIVE MicroRNAs That Regulate Genes Involved IN Cell Cycle ProgressION AND Apoptosis, Experimental Cell Research, October 2015

[논문] MiR-200c downregulates HIF-1α and inhibits migration of lung cancer cells, Cellular & Molecular Biology Letters, April 2019

주8)

[논문] “Proline-rich acidic protein 1 (PRAP1) protects the gastrointestinal epithelium from irradiation-induced apoptosis”. Cellular and Molecular Gastroenterology and Hepatology 2020.

[논문] "A human microbiota-associated murine model for assessing the impact of the vaginal microbiota on pregnancy outcomes". Frontiers in Cellular and Infection Microbiology 2020.

[논문] Neuropeptide Y receptor Y1 (NPYY1) inhibition attenuates intestinal inflammation in mouse models of colitis and human IBD biopsies ex vivo. In Preparation.

[논문] Lactococcus Lactis subsp. cremoris Elicits Protection Against Metabolic Changes Induced by a Western-style Diet, Gastroenterology 2020.

[논문] “Serum Amyloid A1 Is an Epithelial Prorestitutive Factor”. American Journal of Pathology 2018.

[논문] “Lactobacilli Modulate Epithelial Cytoprotection through the Nrf2 Pathway”. Cell Reports 2015.

[학회발표 및 포스터] Poster: “PRAP1 is a novel secreted protein that enhances cytoprotection in the epithelia of the small intestine and uterus”. FASEB Gastrointestinal Tract XVIII Conference: Integrated Biology of the GI Super-Organ. Steamboat Springs, CO 2019.

[학회발표 및 포스터] Oral Presentation: “PRAP1: A Novel Epithelial Secreted Protein”. Experimental Biology NextGen Science: New Discoveries of Graduate Students and Post-Doctoral Fellow Rising Stars. San Diego 2018.

[학회발표 및 포스터] Oral Presentation: “PRAP1: A Novel Epithelial Secreted Protein”. Experimental Biology Pathogenesis of Tissue Inflammation: New Molecules and Mechanisms. San Diego 2018.

[학회발표 및 포스터] Poster: “PRAP1: A Novel Epithelial Secreted Protein”. FASEB Gastrointestinal Tract XVII Conference: Current Biology of the GI Tract, Mucosa, Microbiota and Beyond. Steamboat Springs, CO 2017.

주9)
[논문] MTA1 drives malignant progression and bone metastasis in prostate cancer. Kumar A, Dhar S, Campanelli G, Butt NA, Schallheim JM, Gomez CR, Levenson AS. Mol Oncol. 2018 Sep;12(9):1596-1607
[논문] Targeting MTA1/HIF-1α signaling by pterostilbene in combination with histone deacetylase inhibitor attenuates prostate cancer progression. Butt NA, Kumar A, Dhar S, Rimando S, Akhtar I, Hancock JC, Lage JM, Pound CR, Lewin JR, Gomez CR, Levenson AS. Cancer Med 2017 Nov 6(11): 2673-2685.
[논문] MTA1-activated Epi-microRNA-22 regulates E-cadherin and prostate cancer invasiveness. Dhar S, Kumar A, Gomez CR, Akhtar I, Hancock JC, Lage JM, Pound CR, Levenson AS. FEBS Lett 2017 Mar 591(6):924-933.
[논문] Dietary Pterostilbene is a Novel MTA1-targeted Chemopreventive and Therapeutic Agent in Prostate Cancer. Dhar S*, Kumar A*, Zhang L, Rimando AM, Zhang X, Lewin J, Lage J, Atfi A and Levenson AS. (* Co-first authors). Oncotarget. 2016 Mar 1. doi: 10.18632/oncotarget.7841
[논문] Resveratrol and Pterostilbene epigenetically restore PTEN expression by targeting oncomiRs of the miR-17 family in prostate cancer. Dhar S, Kumar A, Rimando AM, Zhang X, Levenson AS. Oncotarget. 2015 Sep 29; 6(29):27214-26.
[논문] Epigenetic potential of resveratrol and analogs in preclinical models of prostate cancer. Kumar A, Dhar S, Rimando AM, Lage JM, Lewin JR, Zhang X, Levenson AS. Ann N Y Acad Sci. 2015 Aug; 1348(1):1-9.
[논문] Resveratrol regulates PTEN/Akt pathway through inhibition of MTA1/HDAC unit of the NuRD complex in prostate cancer. Dhar S, Kumar A, Li K, Tzivion G, Levenson AS. Biochim Biophys Acta. 2015 Feb; 1853(2):265-75.
[논문] Stilbenes Inhibit Androgen Receptor Expression in 22Rv1 Castrate-resistant Prostate Cancer Cells. Kumar A, Lin S-H, Dhar S, Rimando AM, Levenson AS Journal of Medicinally Active Plants 2014. 3 (Issues 1-4):1-8. Available at:http://scholarworks.umass.edu/jmap/vol3/iss1/2
[논문] Nuclear MTA1 overexpression is associated with aggressive prostate cancer, recurrence and metastasis in African American men. Dias SJ, Zhou X, Ivanovic M, Gailey MP, Dhar S, Zhang L, He Z, Penman AD, Vijayakumar S, Levenson AS. Sci Rep. 2013; 3:2331. doi: 10.1038/srep02331.
[논문] Trimethoxy-resveratrol and piceatannol administered orally suppress and inhibit tumor formation and growth in prostate cancer xenografts. Dias SJ, Li K, Rimando AM, Dhar S, Mizuno CS, Penman AD, Levenson AS. Prostate. 2013 Aug; 73(11):1135-46.
[논문] Pterostilbene acts through metastasis-associated protein 1 to inhibit tumor growth, progression and metastasis in prostate cancer. Li K, Dias SJ, Rimando AM, Dhar S, Mizuno CS, Penman AD, Lewin JR, Levenson AS. PLoS One. 2013; 8(3):e57542. doi: 10.1371/journal.pone.0057542. Epub 2013 Mar 1.
[논문] Resveratrol and prostate cancer: promising role for microRNAs. Dhar S, Hicks C, Levenson AS. Mol Nutr Food Res. 2011 Aug; 55(8):1219-29.
[논문] Lysis of aminobisphosphonate-sensitized MCF-7 breast tumor cells by Vγ9Vδ2 T cells. Dhar S, Chiplunkar SV. Cancer Immunity. 2010 Nov 12; 10:10.
[논문] γδ T cells in cancer immunotherapy: current status and future prospects. Chiplunkar SV, Dhar S, Wesch,D and Kabelitz, D. Immunotherapy (2009) 1(4):663-678
[학회발표 및 포스터] Oral presentation: Society for Neuro-Oncology annual meeting. New Orleans 2018
[학회발표 및 포스터] Poster presentation: Tumor models meeting. Boston 2018
[학회발표 및 포스터] Oral presentation: Research Day, School of Graduate Studies and Health Sciences. UMMC, Jackson 2016

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